Individualized premed. Induction Initially 0.5%. Surgical anaesth 1.5-3% in 7-10 min. Maintenance 1-2.5% in O2/nitrous oxide mixt. Additional 0.5-1% when given w/ O2 alone. Recovery May be reduced to 0.5% near end of surgery or to 0% at the beginning of skin closure.
Transient rise in CSF pressure; hypotension & resp depression; patients at risk for QT prolongation; patients undergoing induced abortion; increased ICP, mitochondrial disorders. Patients who can develop bronchoconstriction. Malignant hyperthermia. Perioperative hyperkalemia, Duchenne muscular dystrophy. Discontinue use of IV dantrolene Na & application of supportive therapy. Augmented resp depression w/ narcotic premed or other resp depressants. Increased carboxyhemoglobin w/ concurrent use of fluorinated inhalation agents. Decrease intellectual function for 2-4 days following anaesth. May affect ability to drive & use machines. Pregnancy & lactation. Childn <2 yr.
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